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Elmar Peschke Selected Research

Insulinoma

5/2014Calcium-signaling components in rat insulinoma β-cells (INS-1) and pancreatic islets are differentially influenced by melatonin.
1/2014Influence of melatonin receptor signalling on parameters involved in blood glucose regulation.
11/2012Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).
5/2012Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets.
10/2011Melatonin inhibits insulin secretion in rat insulinoma β-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2.
8/2010Distribution patterns of calcium-binding proteins in pancreatic tissue of non-diabetic as well as type 2 diabetic rats and in rat insulinoma beta-cells (INS-1).
3/2009Modulation of the cGMP signaling pathway by melatonin in pancreatic beta-cells.
11/2008Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes.
10/2008Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
3/2006Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status.
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Elmar Peschke Research Topics

Disease

13Insulinoma
05/2014 - 09/2002
4Type 2 Diabetes Mellitus (MODY)
08/2015 - 04/2007
2Body Weight (Weight, Body)
01/2014 - 11/2010
1Shock
01/2013
1Chronic Disease (Chronic Diseases)
06/2010
1Diabetic Neuropathies (Diabetic Neuropathy)
09/2009
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
11/2008

Drug/Important Bio-Agent (IBA)

14MelatoninIBA
08/2015 - 09/2002
4Messenger RNA (mRNA)IBA
01/2013 - 03/2006
3Insulin (Novolin)FDA Link
01/2014 - 09/2002
2Hormones (Hormone)IBA
01/2014 - 06/2010
2Melatonin Receptors (Melatonin Receptor)IBA
01/2014 - 10/2011
2Proteins (Proteins, Gene)FDA Link
09/2009 - 10/2005
1CatecholaminesIBA
08/2015
1Blood Glucose (Blood Sugar)IBA
01/2014
1Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA
11/2012
1MT2 Melatonin ReceptorIBA
10/2011
1Protein Isoforms (Isoforms)IBA
10/2011
1Calcium-Binding ProteinsIBA
08/2010
1Soluble Guanylyl CyclaseIBA
03/2009
1Streptozocin (Streptozotocin)FDA Link
11/2008
1GTP-Binding Proteins (G-Protein)IBA
11/2008
1N-acetyltalosaminuronic acid (NAT)IBA
11/2008
1Pertussis ToxinIBA
11/2008
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
10/2008
1Cyclic NucleotidesIBA
10/2008
1MT1 Melatonin ReceptorIBA
03/2006
1Adenosine (Adenocard)FDA LinkGeneric
10/2005
1Glucose (Dextrose)FDA LinkGeneric
09/2002